Here，we developed a comprehensive Cancer ATAC-seq database that aim to provide a large number of available resources on cancer accessible chromatin regions data. The database was annotated with potential functions of accessible regions in the cancer. The current version of CATA documented a total of 2,991,163 ATAC-Peak from 410 tumor samples that was Collected in 23 different cancers. To help researchers better identify some biotherapeutic targets, we have assembled common SNPs, motif changes, expression quantitative trait locus, TFBS, Motif data, methylation, copy number variation, somatic mutation, enhancer, and corresponding clinical data. At the same time, we also provide survival analysis, pathway enrichment and opening region associated analysis which is more convenient for researchers to mine data. CATA database will help elucidate accessible chromatin regions related functions and find potential biological effects and potential therapeutic targets.
Users can search cancer accessible chromatin regions information of cancers through four paths, including search accessible regions by tumor category-bases, search accessible regions by gene, search accessible regions by gene, search accessible regions by TF(transcription factor). Advanced search by genome location.
This page mainly shows summary information about. accessible regions. Including(PEAK ID, genome location, accessible scores, Annotation, TFBS numbers, motif numbers, Enhancer numbers, and so on.) user can click PEAK ID to entering detail page.
The 'Exploration' page is an interactive table of alphanumeric sorting that allows you to quickly search for accessible region and customize filters through 'Tissue', 'Cancer type', 'Annotation', and 'Chromosome'. User can click PEAK-ID quickly entering detail page.
We provide two analysis tools, including Pathway downstream analysis and Associated Accessible Region Analysis.
In order to help users to intuitively view transcriptional regulatory information of accessible regions in the genome, we developed a personalized genome browser using GIVE and added a lot of useful tracks.
We provide Chromatin accessible region data to download, including 24 cancers.